Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 8/20 | 0.44 |
| ▸ | LOX | P28300 | 3/20 | 0.44 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.44 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668247 | 0.86 | — | — | |
| SCHEMBL12362963 | 0.85 | CYP3A4 (0.52) | UHRF1KCNQ2RAB9ACYP17A1CYP3A4 | |
| SCHEMBL22604676 | 0.85 | UHRF1 (0.50) | UHRF1KCNQ2CYP3A4FLT1KDR | |
| Hydrochloric Acid SCHEMBL5083664 | 0.84 | LOXL2 (0.55) | LOXL2LOXLOXL3UHRF1KCNQ2 | |
| SCHEMBL20756914 | 0.82 | UHRF1 (0.46) | UHRF1KCNQ2RAB9ACYP17A1CYP3A4 | |
| SCHEMBL1563564 | 0.81 | CALM1 (0.48) | UHRF1KCNQ2ROCK1FLT1KDR | |
| SCHEMBL25826362 | 0.80 | CYP17A1 (0.49) | UHRF1KCNQ2RAB9ACYP17A1CYP3A4 | |
| SCHEMBL1912303 | 0.78 | DYRK1A (0.56) | ADRB2HRH3NOS3NOS1NOS2 | |
| SCHEMBL19335823 | 0.75 | UHRF1 (0.39) | UHRF1KCNQ2RAB9AHRH3CYP17A1 | |
| SCHEMBL12727962 | 0.75 | POLB (0.63) | LOXL2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024011307-A1 | PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1 AND TREATMENT OF CANCER | THRYV THERAPEUTICS INC. (CA) | 2024-01-18 | — | — | WO | disclosed |