SCHEMBL27323933

SCHEMBL27323933

COC(=S)c1cccc(F)c1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
GAA P10253 2/20 0.46
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
NPC1 O15118 4/20 0.38
HPGD P15428 3/20 0.38
MAPT P10636 3/20 0.38
KDM4E B2RXH2 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
TAS1R2 Q8TE23 1/20 0.36
RAB9A P51151 2/20 0.36
KMT2A Q03164 2/20 0.35
CES2 O00748 1/20 0.35
BCHE P06276 1/20 0.35
CES1 P23141 1/20 0.35
HDAC4 P56524 1/20 0.34
ALB P02768 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27721374 0.80 ALDH1A1 (0.46) ALDH1A1GAAESR1ESR2NPC1
SCHEMBL9539465 0.78 ESR1 (0.45) ALDH1A1GAAESR1ESR2NPC1
SCHEMBL30353807 0.77 LMNA (0.50) ALDH1A1GAAESR1ESR2HPGD
SCHEMBL5334254 0.77 LMNA (0.50) ALDH1A1GAAESR1ESR2HPGD
SCHEMBL24800775 0.76 ESR1 (0.44) ALDH1A1GAAESR1ESR2NPC1
SCHEMBL9539597 0.76 ESR1 (0.44) ALDH1A1GAAESR1ESR2NPC1
SCHEMBL8309467 0.76 GAA (0.35) ALDH1A1GAAKMT2A
SCHEMBL7135408 0.73 ESR1 (0.47) ALDH1A1GAAESR1ESR2SMN1; SMN2
SCHEMBL16959719 0.73 ESR1 (0.47) ALDH1A1GAAESR1ESR2SMN1; SMN2
SCHEMBL9539463 0.72 ESR1 (0.51) ALDH1A1GAAESR1ESR2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1037436-C New herbicides RHONE POULENC AGRICULTURE (GB) 1998-02-18 CN disclosed
CN-1082539-A New herbicides RHONE POULENC AGRICULTURE (GB) 1994-02-23 CN disclosed