Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27855763 | 0.75 | GAA (0.30) | MAPTL3MBTL1 | |
| SCHEMBL28327769 | 0.75 | CYP3A4 (0.32) | BRD4CREBBPMAPT | |
| SCHEMBL27518193 | 0.75 | RPS6KA3 (0.31) | MEN1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL28195323 | 0.75 | BRD4 (0.40) | BRD4CREBBPALDH1A1 | |
| SCHEMBL27492674 | 0.72 | OTUD7B (0.33) | KMT2AALDH1A1 | |
| SCHEMBL28301796 | 0.72 | ERN1 (0.35) | — | |
| SCHEMBL18209134 | 0.70 | ALOX5 (0.41) | ALOX5PARP1MEN1KMT2ABRD4 | |
| SCHEMBL18666567 | 0.69 | ALOX5 (0.48) | ALOX5PARP1MEN1KMT2ABRD4 | |
| SCHEMBL7634443 | 0.68 | ALOX5 (0.46) | ALOX5PARP1MEN1KMT2ABRD4 | |
| SCHEMBL17968128 | 0.67 | ALOX5 (0.45) | ALOX5PARP1MEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101341129-B | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2011-12-14 | — | — | CN | claimed |
| CN-101341129-A | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-01-07 | — | — | CN | claimed |
| CN-101137412-A | Substituted biaryl compounds as factor xia inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2008-03-05 | — | — | CN | claimed |
| CN-107652249-B | Synthesis process of 1, 4 benzoxazinone compound | 新昌县勤勉生物医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-110418790-A | Imidazo pyrroles's ketone compound as p53-MDM2 inhibitor | LUOXIN BIOTECHNOLOGY SHANGHAI CO LTD | 2019-11-05 | — | — | CN | disclosed |
| CN-108884044-A | PIPERIDINE DERIVATIVE | 大塚制药株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-107635558-A | Bu Luomo domain inhibitor | 赛尔基因昆蒂赛尔研究公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-101341129-B | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2011-12-14 | — | — | CN | disclosed |
| CN-101341129-A | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-01-07 | — | — | CN | disclosed |
| CN-101137412-A | Substituted biaryl compounds as factor xia inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2008-03-05 | — | — | CN | disclosed |
| CN-1032479-A | Replace azoles and its method for making of piperazine compounds and weeding purpose | SCHERING AG (DE) | 1989-04-26 | — | — | CN | disclosed |
| CN-87100658-A | 1,4-benzoxazine derivatives, their preparation and application | — | 1987-09-09 | — | — | CN | disclosed |