SCHEMBL2732871

SCHEMBL2732871

CCCCn1c(N)nc2ncn(CO)c2c1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 9/20 0.45
PDE4B Q07343 8/20 0.45
PDE4C Q08493 8/20 0.45
PDE4D Q08499 8/20 0.45
ADORA2A P29274 5/20 0.45
ADORA2B P29275 1/20 0.45
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
BRD4 O60885 1/20 0.39
BRD2 P25440 1/20 0.39
BRD3 Q15059 1/20 0.39
BRDT Q58F21 1/20 0.39
TLR8 Q9NR97 1/20 0.38
LMNA P02545 1/20 0.37
ESR1 P03372 1/20 0.37
CYP1A2 P05177 1/20 0.37
MAPT P10636 1/20 0.37
NFKB1 P19838 1/20 0.37
ACHE P22303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7809883 0.87 ADORA2A (0.47) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL27762592 0.85 PDE4A (0.41) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL9059983 0.84 PDE4A (0.55) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL20969999 0.76 SMN1; SMN2 (0.45) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL26248690 0.70 ADORA2A (0.54) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL6272735 0.69 PDE4A (0.59) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL8326031 0.69 RXFP1 (0.39) ADORA2AADORA2BGAA
SCHEMBL6270755 0.69 ADORA2B (0.46) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL19090437 0.68 BRD4 (0.59) PDE4APDE4BPDE4CPDE4DADORA2A
SCHEMBL9586814 0.68 PDE4A (0.55) PDE4APDE4BPDE4CPDE4DADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210147502-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE UNIV VIRGINIA COMMONWEALTH (US) 2021-05-20 US disclosed
US-20200384135-A1 CANCER IMAGING WITH THERAPY: THERANOSTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2020-12-10 US disclosed
EP-3004153-B1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE UNIV VIRGINIA COMMONWEALTH (US) 2019-10-30 EP disclosed
US-10166300-B2 Tripartite cancer theranostic nucleic acid constructs VIRGINIA COMMONWEALTH UNIVERSITY (US) 2019-01-01 US disclosed
US-20180305429-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE UNIV VIRGINIA COMMONWEALTH (US) 2018-10-25 US disclosed
US-9951114-B2 Recombinant cancer therapeutic cytokine VIRGINIA COMMONWEALTH UNIVERSITY (US) 2018-04-24 US disclosed
EP-3003022-B1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS UNIV VIRGINIA COMMONWEALTH (US) 2017-11-22 EP disclosed
EP-3004872-B1 MDA-9/SYNTENIN PROMOTER TO IMAGE AND TREAT METASTATIC CANCER CELLS UNIV VIRGINIA COMMONWEALTH (US) 2017-10-18 EP disclosed
US-9750823-B2 Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics UNIV VIRGINIA COMMONWEALTH (US) 2017-09-05 US disclosed
US-9701985-B2 mda-9/syntenin promoter to image and treat metastatic cancer cells VIRGINIA COMMONWEALTH UNIVERSITY (US) 2017-07-11 US disclosed
EP-3003022-A1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS Virginia Commonwealth University (US) 2016-04-13 EP disclosed
EP-3004153-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE Virginia Commonwealth University (US) 2016-04-13 EP disclosed
EP-3003393-A2 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS The Johns Hopkins University (US) 2016-04-13 EP disclosed
WO-2014209553-A1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2014-12-31 WO disclosed
WO-2014197598-A2 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS THE JOHNS HOPKINS UNIVERSITY (US) 2014-12-11 WO disclosed
WO-2014197535-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2014-12-11 WO disclosed
US-20140227182-A1 CANCER IMAGING WITH THERAPY: THERANOSTICS THE JOHNS HOPKINS UNIVERSITY (US) 2014-08-14 US disclosed
US-20130263296-A1 CANCER IMAGING WITH THERAPY: THERANOSTICS THE JOHNS HOPKINS UNIVERSITY (US) 2013-10-03 US disclosed
EP-2633063-A2 CANCER IMAGING WITH THERAPY: THERANOSTICS Virginia Commonwealth University (US) 2013-09-04 EP disclosed
WO-2012058522-A2 CANCER IMAGING WITH THERAPY: THERANOSTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2012-05-03 WO disclosed