Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylpropion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylpropion SCHEMBL15484 | 1.00 | PGR (1.00) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL15483 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL506145 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL7715371 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL22614735 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL5546846 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL18141848 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL3051269 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL9101119 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL5244701 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12930 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260131089-A1 | DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY | APTARGROUP, INC. (US) | 2026-05-14 | — | — | US | claimed |
| US-12611388-B1 | Weight loss formulation and methods | ALLEN GREGORY SETH (US) | 2026-04-28 | — | — | US | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| US-20260083709-A1 | COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA | APNIMED INC DELAWARE (US) | 2026-03-26 | — | — | US | claimed |
| US-20260086062-A1 | IMMOBILIZATION STRATEGIES FOR ENHANCING SENSITIVITY OF ELECTROCHEMICAL APTAMER-BASED SENSORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2026-03-26 | — | — | US | claimed |
| EP-4271674-B9 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12570642-B2 | GLP-IR modulating compounds | GILEAD SCIENCES, INC. (US) | 2026-03-10 | — | — | US | claimed |
| US-20260056214-A1 | DIAGNOSING AND TREATING END-STAGE RENAL DISEASE (ESRD) IN OBESE SUBJECTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2026-02-26 | — | — | US | claimed |
| EP-4699609-A2 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2026-02-25 | — | — | EP | claimed |
| EP-4691554-A2 | GLP-1R MODULATING COMPOUNDS | Gilead Sciences, Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| US-5096712-A | METHOD FOR ENHANCING PERFORMANCE SO AS TO IMPROVE VIGOR AND DECREASE FATIGUE, CONFUSION, TENSION, AND ANXIETY | INTERNEURON PHARMACEUTICALS, INC. (US) | 1992-03-17 | — | — | US | claimed |
| US-5019594-A | Method for decreasing appetite | INTERNEURON PHARMACEUTICALS, INC. (US) | 1991-05-28 | — | — | US | claimed |
| EP-0384267-A2 | Therapeutic system for the sustained and controlled transdermal or transmucosal delivery of active agents | LTS Lohmann Therapie-Systeme GmbH & Co. KG (DE) | 1990-08-29 | — | — | EP | claimed |
| EP-0384266-A2 | Therapeutic system for the sustained and controlled transdermal or transmucosal delivery of active agents | LTS Lohmann Therapie-Systeme GmbH & Co. KG (DE) | 1990-08-29 | — | — | EP | claimed |
| US-4933324-A | Fatty acid-neuroactive drug conjugate as a prodrug | LUITPOLD PHARMACEUTICALS, INC. | 1990-06-12 | — | — | US | claimed |
| EP-0095123-B1 | SUSTAINED RELEASE DIETHYLPROPION COMPOSITIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-09-02 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0152379-A2 | Process for preparing pharmaceutical compositions containing unilamellar liposomes | CIBA-GEIGY AG (CH) | 1985-08-21 | — | — | EP | claimed |
| US-4255439-A | Means and method for aiding individuals to stop smoking | COOPER IRVING | 1981-03-10 | — | — | US | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |