Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylpropion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.93 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.93 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.93 |
| ▸ | HTR2A | P28223 | 1/20 | 0.93 |
| ▸ | HRH1 | P35367 | 1/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.93 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylpropion SCHEMBL506145 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL22614735 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL15483 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL7715371 | 0.98 | PGR (0.96) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL5546846 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL18141848 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL5244701 | 0.96 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL27330 | 0.96 | PGR (1.00) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL15484 | 0.96 | PGR (1.00) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Diethylpropion SCHEMBL3051269 | 0.93 | PGR (0.93) | PGRADRA2AADRA2BHTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298948-B1 | CERAMIC FOR DECORATIVE PART AND DECORATIVE PART COMPRISING THE SAME | KYOCERA CORP (JP) | 2019-05-01 | — | — | EP | claimed |
| EP-1611591-B1 | X-RAY TUBE CATHODE ASSEMBLY AND INTERFACE REACTION JOINING PROCESS | KONINKL PHILIPS ELECTRONICS NV (NL) | 2012-06-06 | — | — | EP | claimed |
| EP-0331725-B1 | RARE GAS-HALOGEN EXCIMER LASER | ACCULASE INC (US) | 1994-12-28 | — | — | EP | claimed |
| WO-2013004637-A2 | PROCESS FOR PRODUCING A POROUS CERAMIC | UNIVERSITÄT BAYREUTH (DE) | 2013-01-10 | — | — | WO | disclosed |