Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942096 | 0.92 | RAB9A (0.55) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL2723359 | 0.90 | ITGB3 (0.50) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL2733236 | 0.82 | MAPT (0.42) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL31679065 | 0.72 | GFER (0.53) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL6732278 | 0.72 | GFER (0.53) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL2724952 | 0.71 | GFER (0.44) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| Iodide SCHEMBL16906337 | 0.70 | GFER (0.44) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL4893846 | 0.70 | KMT2A (0.55) | RAB9ANPC1HTTMAPTKMT2A | |
| SCHEMBL2727185 | 0.70 | RAB9A (0.42) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL2723746 | 0.69 | MTNR1A (0.50) | RAB9ASMN1; SMN2NPC1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635281-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | University Of Hawaii (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061505-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | UNIVERSITY OF HAWAII (US) | 2012-05-10 | — | — | WO | claimed |