Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 11/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2130899 | 1.00 | MGLL (0.42) | MGLLCCR2KCNH2CYP2D6MCHR1 | |
| SCHEMBL2130123 | 0.94 | MGLL (0.42) | MGLLCCR2KCNH2CYP2D6MCHR1 | |
| SCHEMBL2132714 | 0.93 | MGLL (0.43) | MGLLCCR2KCNH2CYP2D6MCHR1 | |
| SCHEMBL2723057 | 0.93 | MGLL (0.43) | MGLLCCR2KCNH2CYP2D6MCHR1 | |
| SCHEMBL2135736 | 0.91 | MGLL (0.49) | MGLLKCNH2CYP2D6MCHR1SCN9A | |
| SCHEMBL2132826 | 0.90 | MGLL (0.41) | MGLLCYP2D6MCHR1 | |
| SCHEMBL2129567 | 0.86 | SLC6A7 (0.49) | MGLLCCR2KCNH2MCHR1SLC6A7 | |
| SCHEMBL2129647 | 0.86 | CCR2 (0.45) | MGLLCCR2CYP2D6MCHR1SLC6A7 | |
| SCHEMBL2722500 | 0.86 | CCR2 (0.45) | MGLLCCR2CYP2D6MCHR1SLC6A7 | |
| SCHEMBL2732825 | 0.85 | CCR2 (0.43) | MGLLCCR2KCNH2CYP2D6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630139-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-08-28 | — | — | EP | claimed |
| WO-2012054721-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICAL NV (BE) | 2012-04-26 | — | — | WO | claimed |