Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530872 | 0.82 | MAPT (0.56) | KCNJ1MAPTPOLBRXFP1MEN1 | |
| SCHEMBL2732279 | 0.81 | KCNJ1 (0.57) | KCNJ1MAPTPOLBKMT2ABLM | |
| SCHEMBL15018094 | 0.78 | LMNA (0.50) | KCNJ1MAPTPOLBMEN1KMT2A | |
| SCHEMBL15017706 | 0.78 | ALDH1A1 (0.42) | KCNJ1MAPTPOLBRXFP1MEN1 | |
| SCHEMBL16122487 | 0.75 | KCNJ1 (0.55) | KCNJ1MAPTPOLBBLMTDP1 | |
| SCHEMBL18216572 | 0.74 | KCNJ1 (0.51) | KCNJ1MAPTPOLBMEN1KMT2A | |
| SCHEMBL1135124 | 0.73 | SMN1; SMN2 (0.46) | MAPTPOLBMEN1KMT2AESR2 | |
| SCHEMBL14677406 | 0.73 | SMN1; SMN2 (0.46) | MAPTMEN1KMT2AESR2CYP3A4 | |
| SCHEMBL10287706 | 0.73 | KCNH2 (0.57) | KCNJ1KCNH2 | |
| SCHEMBL2732275 | 0.73 | KCNH2 (0.57) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |