Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.69 |
| ▸ | GCGR | P47871 | 12/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.69 |
| ▸ | FRK | P42685 | 3/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.69 |
| ▸ | GSK3B | P49841 | 3/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.69 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.69 |
| ▸ | BRAF | P15056 | 2/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.62 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.61 |
| ▸ | PRKACA | P17612 | 2/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371873 | 0.92 | KDM4E (0.67) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387860 | 0.83 | KDM4E (0.83) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL15075603 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL19868925 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL2650684 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7090083 | 0.81 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4285506 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6168758 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5098384 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6934304 | 0.80 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1050126-C | Tri-substituted imidazoles, their preparation and use and pharmaceutical compositions containing them | SMITHKLINE BEECHAM CORP (US) | 2000-03-08 | — | — | CN | claimed |
| CN-1129447-A | Trisubstituted imidazoles having multiple therapeutic effects | SMITHKLINE BEECHAM CORP (US) | 1996-08-21 | — | — | CN | claimed |
| CN-1050126-C | Tri-substituted imidazoles, their preparation and use and pharmaceutical compositions containing them | SMITHKLINE BEECHAM CORP (US) | 2000-03-08 | — | — | CN | disclosed |
| CN-1218801-A | Tri-substituted imidazoles, and process of their preparation and using the same and having their pharmic composition | SMITHKLINE BEECHAM CORP (US) | 1999-06-09 | — | — | CN | disclosed |
| CN-1129447-A | Trisubstituted imidazoles having multiple therapeutic effects | SMITHKLINE BEECHAM CORP (US) | 1996-08-21 | — | — | CN | disclosed |