Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1369724 | 0.84 | PTGDR2 (0.48) | USP2HSP90AA1HSP90AB1ALDH1A1RAB9A | |
| SCHEMBL471624 | 0.78 | USP2 (0.54) | USP2HSP90AA1HSP90AB1ALDH1A1RAB9A | |
| SCHEMBL2170651 | 0.78 | HPGD (0.57) | USP2HSP90AA1HSP90AB1ALDH1A1RAB9A | |
| SCHEMBL1369782 | 0.77 | PTGDR2 (0.43) | USP2HSP90AA1HSP90AB1ALDH1A1RAB9A | |
| SCHEMBL1085171 | 0.77 | KDM4E (0.47) | ALDH1A1MAPK1LMNA | |
| SCHEMBL3552169 | 0.76 | USP2 (0.52) | USP2HSP90AA1HSP90AB1ALDH1A1RAB9A | |
| SCHEMBL3341268 | 0.76 | DGAT1 (0.54) | USP2HSP90AA1HSP90AB1ALDH1A1RAB9A | |
| SCHEMBL3472808 | 0.76 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1LMNA | |
| SCHEMBL9173722 | 0.76 | WDR5 (0.42) | ALDH1A1HPGD | |
| SCHEMBL17505003 | 0.76 | DGAT1 (0.53) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |