SCHEMBL273369

SCHEMBL273369

O=c1c(O)c(CN2CCC3(CC2)OCCO3)ccn1Cc1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 12/20 0.72
EGLN1 Q9GZT9 12/20 0.72
ALDH1A1 P00352 2/20 0.46
TSHR P16473 2/20 0.46
KDM4E B2RXH2 2/20 0.46
HTT P42858 2/20 0.46
GAA P10253 1/20 0.46
SIGMAR1 Q99720 2/20 0.44
TMEM97 Q5BJF2 1/20 0.44
CYP2D6 P10635 2/20 0.40
ADORA2A P29274 1/20 0.40
TP53 P04637 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5270118 0.96 VEGFA (0.66) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL272666 0.84 VEGFA (0.81) VEGFAEGLN1ALDH1A1KDM4EHTT
SCHEMBL278202 0.84 VEGFA (1.00) VEGFAEGLN1ALDH1A1KDM4EHTT
SCHEMBL273037 0.83 EGLN1 (0.87) VEGFAEGLN1ALDH1A1KDM4EHTT
SCHEMBL271963 0.82 EGLN1 (0.85) VEGFAEGLN1KDM4EHTTCYP2D6
SCHEMBL273696 0.82 EGLN1 (0.85) VEGFAEGLN1KDM4EHTTCYP2D6
SCHEMBL277668 0.82 EGLN1 (0.85) VEGFAEGLN1KDM4EHTTCYP2D6
SCHEMBL12598825 0.80 EGLN1 (0.73) VEGFAEGLN1ALDH1A1KDM4EHTT
SCHEMBL272076 0.80 VEGFA (0.85) VEGFAEGLN1ALDH1A1KDM4EHTT
SCHEMBL272116 0.80 VEGFA (0.85) VEGFAEGLN1ALDH1A1KDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496082-B1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC (US) 2016-10-12 EP claimed
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2015-06-11 US claimed
US-8999971-B2 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha AERPIO THERAPEUTICS INC. (US) 2015-04-07 US claimed
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2014-12-11 US claimed
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC. (US) 2013-06-20 US claimed
EP-2496082-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA Aerpio Therapeutics Inc. (US) 2012-09-12 EP claimed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 US claimed
WO-2011057112-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO claimed
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2007-11-22 US claimed
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-10-20 US claimed
CN-116018136-A Hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of aging-related disorders 百爱及生物医药公司 2023-04-25 CN disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS BioAge Labs, Inc. 2021-11-18 US disclosed
EP-3698794-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS Aerpio Therapeutics, Inc. (US) 2020-08-26 EP disclosed
US-7790748-B2 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones WARNER CHILCOTT COMPANY, LLC (US) 2010-09-07 US disclosed
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2007-11-22 US disclosed
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-10-20 US disclosed
US-6930117-B2 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-08-16 US disclosed
US-20040097560-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2004-05-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885ALDH1A1 505/4885
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS HIF1AN, HIF1A, P4HA1 VEGFA 384/4885EGLN1 11/4885ALDH1A1 374/4885
US-20040097560-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, CYP51A1, CD4 VEGFA 3112/4885EGLN1 926/4885ALDH1A1 224/4885
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, IFNG, CD4 VEGFA 2758/4885EGLN1 1060/4885ALDH1A1 442/4885
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, IFNG, CD4 VEGFA 3064/4885EGLN1 1182/4885ALDH1A1 495/4885
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885ALDH1A1 505/4885
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885ALDH1A1 505/4885
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885ALDH1A1 505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.