Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27319542 | 0.83 | KLKB1 (0.44) | KLKB1HPGDLMNAF7MAPT | |
| SCHEMBL27317866 | 0.81 | KLKB1 (0.44) | KLKB1HPGDLMNAF7MAPT | |
| SCHEMBL27345265 | 0.80 | KLKB1 (0.50) | KLKB1HPGDLMNASENP1MAPT | |
| SCHEMBL27320583 | 0.78 | BCHE (0.46) | ALDH1A1BCHEACHE | |
| SCHEMBL27415918 | 0.78 | HPGD (0.40) | KLKB1HPGDLMNAF7MAPT | |
| SCHEMBL27401020 | 0.77 | PPARG (0.50) | KLKB1HPGDLMNAF7TPSAB1 | |
| SCHEMBL12953853 | 0.74 | MAPT (0.62) | KLKB1HPGDMAPTTPSAB1POLB | |
| SCHEMBL27419335 | 0.74 | KLKB1 (0.44) | KLKB1MAPTTPSAB1POLBPLG | |
| SCHEMBL8531301 | 0.74 | TSHR (0.59) | KLKB1 | |
| SCHEMBL27321553 | 0.73 | KLKB1 (0.46) | KLKB1HPGDMAPTPOLBPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046268-C | Indolin-2-one derivatives | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1999-11-10 | — | — | CN | disclosed |
| CN-1117727-A | Indolin-2-one derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1996-02-28 | — | — | CN | disclosed |