Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 4/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.44 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17975956 | 0.81 | GHSR (0.53) | TPSAB1NPC1GHSRROCK2CNR1 | |
| SCHEMBL4743832 | 0.77 | CA2 (0.67) | NPC1ROCK2HPGD | |
| SCHEMBL8919908 | 0.77 | ALDH1A1 (0.58) | NPC1GHSRKLKB1ALDH1A1LOXL2 | |
| SCHEMBL4548599 | 0.77 | TPSAB1 (0.48) | TPSAB1PRSS1KLKB1 | |
| SCHEMBL1189878 | 0.77 | CA12 (0.59) | NPC1HPGDALDH1A1 | |
| SCHEMBL545945 | 0.77 | SMN1; SMN2 (0.65) | NPC1LMNA | |
| SCHEMBL4548528 | 0.77 | TPSAB1 (0.48) | TPSAB1PRSS1KLKB1 | |
| SCHEMBL17976392 | 0.77 | ABAT (0.61) | KLKB1ALDH1A1 | |
| SCHEMBL23747520 | 0.76 | RAB9A (0.73) | NPC1CNR1 | |
| SCHEMBL16378812 | 0.76 | NPC1 (0.64) | TPSAB1NPC1ROCK2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046268-C | Indolin-2-one derivatives | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1999-11-10 | — | — | CN | disclosed |
| CN-1117727-A | Indolin-2-one derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1996-02-28 | — | — | CN | disclosed |