Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | KLK1 | P06870 | 2/20 | 0.41 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27323392 | 0.81 | KLKB1 (0.50) | KLKB1RAB9AHRH3MAPTNPC1 | |
| SCHEMBL27337079 | 0.80 | KLKB1 (0.48) | KLKB1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27905664 | 0.77 | RAB9A (0.58) | KLKB1RAB9ASMN1; SMN2HRH3MAPT | |
| SCHEMBL8531301 | 0.76 | TSHR (0.59) | KLKB1TSHR | |
| SCHEMBL27321557 | 0.75 | KLKB1 (0.39) | KLKB1ALDH1A1HRH3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL31647027 | 0.74 | TSHR (0.58) | KLKB1PLGKLK1KLK6TSHR | |
| SCHEMBL27543336 | 0.74 | KLKB1 (0.46) | KLKB1SMN1; SMN2HRH3 | |
| SCHEMBL8919908 | 0.74 | ALDH1A1 (0.58) | KLKB1RAB9AALDH1A1HRH3NPC1 | |
| SCHEMBL24130698 | 0.72 | RAB9A (0.64) | RAB9ASMN1; SMN2ALDH1A1HRH3MAPT | |
| SCHEMBL16837072 | 0.72 | KDM4E (0.46) | KLKB1SMN1; SMN2HRH3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046268-C | Indolin-2-one derivatives | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1999-11-10 | — | — | CN | disclosed |
| CN-1117727-A | Indolin-2-one derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1996-02-28 | — | — | CN | disclosed |