Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733750 | 1.00 | MAPT (0.55) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL2733752 | 1.00 | MAPT (0.55) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL10059278 | 0.91 | HTR2A (0.54) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL15346967 | 0.91 | HTR2A (0.54) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL6421208 | 0.89 | HTR2A (0.52) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL15346977 | 0.89 | HTR2A (0.52) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL15356237 | 0.87 | MAPT (0.56) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL18780144 | 0.86 | ACE (0.54) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL2732566 | 0.84 | ACE (0.53) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL2732564 | 0.84 | ACE (0.53) | MAPTKDM4EMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3756665-A1 | INTERVAL THERAPY FOR THE TREATMENT OF EYE DISEASES | Ramot at Tel-Aviv University Ltd. (IL) | 2020-12-30 | — | — | EP | claimed |
| US-9629824-B2 | Indole derivatives and process for their preparation | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2017-04-25 | — | — | US | claimed |
| US-20160220535-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-08-04 | — | — | US | claimed |
| US-9309196-B2 | Indole derivatives and process for their preparation | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-04-12 | — | — | US | claimed |
| EP-2632897-B1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO KGAA (DE) | 2014-10-01 | — | — | EP | claimed |
| US-20130289090-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-10-31 | — | — | US | claimed |
| EP-2632897-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Merz Pharma GmbH & Co. KGaA (DE) | 2013-09-04 | — | — | EP | claimed |
| WO-2012055945-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-05-03 | — | — | WO | claimed |
| US-20220193035-A1 | INDOLE COMPOUNDS FOR USE IN NEURORESTORATION | GALIMEDIX THERAPEUTICS, INC. (US) | 2022-06-23 | — | — | US | disclosed |
| EP-3756665-A1 | INTERVAL THERAPY FOR THE TREATMENT OF EYE DISEASES | Ramot at Tel-Aviv University Ltd. (IL) | 2020-12-30 | — | — | EP | disclosed |
| US-9717772-B2 | Interval therapy for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2017-08-01 | — | — | US | disclosed |
| US-9629824-B2 | Indole derivatives and process for their preparation | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2017-04-25 | — | — | US | disclosed |
| US-20160220535-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-08-04 | — | — | US | disclosed |
| US-9309196-B2 | Indole derivatives and process for their preparation | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-04-12 | — | — | US | disclosed |
| EP-2632897-B1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO KGAA (DE) | 2014-10-01 | — | — | EP | disclosed |
| US-20130289090-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289090-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-10-31 | — | — | US | disclosed |
| EP-2632897-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Merz Pharma GmbH & Co. KGaA (DE) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012055945-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012055945-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220193035-A1 | INDOLE COMPOUNDS FOR USE IN NEURORESTORATION | AANAT, INMT, TPH2 | MAPT 23/4885KDM4E 2447/4885MEN1 1906/4885 |
| US-20130289090-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | HCRTR1, APP, C1R | MAPT 342/4885KDM4E 4491/4885MEN1 979/4885 |
| US-20160220535-A1 | INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | HCRTR1, APP, C1R | MAPT 227/4885KDM4E 4519/4885MEN1 853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.