Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 13/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27350720 | 0.81 | PIN1 (0.46) | KDM4EALDH1A1SMN1; SMN2PIN1GALR2 | |
| SCHEMBL28855933 | 0.81 | PGK1 (0.47) | KDM4EALDH1A1SMN1; SMN2PIN1LMNA | |
| SCHEMBL5676312 | 0.78 | PIN1 (0.46) | KDM4EALDH1A1SMN1; SMN2PIN1MAPT | |
| SCHEMBL8136031 | 0.75 | TYMS (0.40) | ALDH1A1TYMSGALR2LMNAPOLB | |
| SCHEMBL1571289 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2ABL1BCR | |
| SCHEMBL31648508 | 0.72 | PIN1 (0.50) | KDM4EALDH1A1SMN1; SMN2PIN1 | |
| SCHEMBL22777562 | 0.71 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2ABL1BCR | |
| SCHEMBL30952054 | 0.71 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2ABL1BCR | |
| SCHEMBL31460824 | 0.71 | ALDH1A1 (0.51) | KDM4EALDH1A1SMN1; SMN2ABL1BCR | |
| SCHEMBL27350722 | 0.71 | KMT2A (0.51) | ALDH1A1SMN1; SMN2LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1044245-C | Tricyclic Dicarbonyl derivatives | HAFFMANN LA ROCHE AG F (DE) | 1999-07-21 | — | — | CN | disclosed |
| CN-1149295-A | Tricyclic Dicarbonyl derivatives | HOFFMANN LA ROCHE (CH) | 1997-05-07 | — | — | CN | disclosed |