Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18169673 | 0.84 | LMNA (0.48) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL5255379 | 0.83 | LMNA (0.47) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL18726003 | 0.82 | CSNK1E (0.34) | LMNASMN1; SMN2GAACSNK1ERORC | |
| SCHEMBL4204778 | 0.78 | — | — | |
| SCHEMBL18726006 | 0.77 | GAA (0.55) | LMNASMN1; SMN2GAACNR1KDM4E | |
| SCHEMBL5803020 | 0.74 | RIPK1 (0.39) | LMNANPC1RAB9A | |
| SCHEMBL2757925 | 0.73 | LMNA (0.60) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL28186001 | 0.73 | LMNA (0.60) | LMNASMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL25802126 | 0.72 | LMNA (0.42) | LMNASMN1; SMN2GAACNR1CSNK1E | |
| SCHEMBL25799678 | 0.72 | GRM5 (0.45) | LMNASMN1; SMN2GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632255-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058203-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |