Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733875 | 0.83 | LMNA (0.47) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2324149 | 0.79 | POLB (0.54) | LMNANPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL14026991 | 0.75 | DPP7 (0.44) | LMNANPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL29135819 | 0.74 | KMT2A (0.59) | LMNANPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL18129500 | 0.74 | SMN1; SMN2 (0.49) | LMNANPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL18169673 | 0.74 | LMNA (0.48) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10756230 | 0.73 | ALDH1A1 (0.36) | LMNANPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL2757925 | 0.71 | LMNA (0.60) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1026847 | 0.71 | — | — | |
| SCHEMBL28186001 | 0.71 | LMNA (0.60) | LMNANPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797054-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI Pharmaceuticals, Inc. (US) | 2007-06-20 | — | — | EP | claimed |
| WO-2006017443-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | WO | claimed |