Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.53 |
| ▸ | GALR2 | O43603 | 4/20 | 0.52 |
| ▸ | GALR1 | P47211 | 3/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482241 | 0.94 | MEN1 (0.70) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL12487939 | 0.93 | MEN1 (0.68) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL27345375 | 0.85 | MEN1 (0.69) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL27317919 | 0.81 | EGFR (0.49) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL27344279 | 0.81 | MEN1 (0.45) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL12485614 | 0.80 | MEN1 (0.87) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL16587370 | 0.80 | MEN1 (0.65) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL27317916 | 0.80 | TRPV1 (0.47) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL12488156 | 0.79 | GALR2 (0.67) | MEN1KMT2ARAB9ANPC1EGFR | |
| SCHEMBL10187337 | 0.77 | MEN1 (0.81) | MEN1KMT2ARAB9ANPC1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |