Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27401069 | 0.88 | KMO (0.52) | ABL1BCRNPC1RAB9AALDH1A1 | |
| SCHEMBL8799831 | 0.84 | LMNA (0.58) | ABL1BCRNPC1RAB9AALDH1A1 | |
| SCHEMBL27330852 | 0.81 | ABL1 (0.66) | ABL1BCRNPC1RAB9AALDH1A1 | |
| SCHEMBL12486547 | 0.79 | ABL1 (0.73) | ABL1BCRNPC1RAB9APIK3CB | |
| SCHEMBL27320743 | 0.79 | ABL1 (0.57) | ABL1BCRNPC1RAB9AALDH1A1 | |
| SCHEMBL1095507 | 0.79 | MAPT (0.52) | ABL1BCRNPC1RAB9AALDH1A1 | |
| SCHEMBL8809069 | 0.77 | ABL1 (0.68) | ABL1BCRALDH1A1EGFRGAA | |
| SCHEMBL8799812 | 0.77 | JAK2 (0.53) | ABL1BCREGFRJAK2MAPT | |
| SCHEMBL27335948 | 0.76 | ABL1 (0.54) | ABL1BCRNPC1RAB9AALDH1A1 | |
| SCHEMBL27335946 | 0.76 | PIK3CB (0.59) | ABL1BCRNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |