Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27261695 | 0.80 | ALDH1A1 (0.38) | NOTUMHTTALDH1A1TSHR | |
| SCHEMBL4984056 | 0.73 | KMT2A (0.48) | NOTUMMEN1KMT2ASCN2AUSP2 | |
| SCHEMBL27279518 | 0.71 | KDM4E (0.43) | MAPTALDH1A1TSHRLMNA | |
| SCHEMBL5859165 | 0.70 | NOTUM (0.59) | NOTUMMEN1KMT2AUSP2MAPT | |
| SCHEMBL8593659 | 0.69 | NOTUM (0.79) | NOTUMMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5860023 | 0.68 | MEN1 (0.68) | NOTUMHTTMEN1KMT2AUSP2 | |
| SCHEMBL2280011 | 0.67 | NOTUM (1.00) | NOTUMMEN1KMT2APKMUSP2 | |
| Hydrochloric Acid SCHEMBL19150407 | 0.67 | MEN1 (0.67) | NOTUMHTTMEN1KMT2AUSP2 | |
| SCHEMBL27260960 | 0.67 | KMO (0.39) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL31443161 | 0.66 | ALDH1A1 (0.44) | HTTMEN1KMT2APKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1060173-C | Heterocyclic compound with activity against diabetes and preparation and application of same | MITSUTAKA CO LTD (JP) | 2001-01-03 | — | — | CN | disclosed |
| CN-1118781-A | Heterocyclic compound with activity against diabetes and preparation and application of same | MITSUTAKA CO LTD (JP) | 1996-03-20 | — | — | CN | disclosed |