Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | TOP2A | P11388 | 7/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27339827 | 0.84 | TOP2A (0.58) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL10915179 | 0.82 | TOP2A (0.58) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL10627007 | 0.82 | KCNH2 (0.48) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL7998227 | 0.81 | KDM4E (0.52) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL4714374 | 0.81 | KDM4E (0.52) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL29793501 | 0.81 | KDM4E (0.52) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL2670640 | 0.79 | TOP2A (0.50) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL4715010 | 0.79 | KDM4E (0.57) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL4482132 | 0.79 | ALDH1A1 (0.58) | KDM4ETOP2ATOP2BALDH1A1POLB | |
| SCHEMBL4714357 | 0.78 | KDM4E (0.49) | KDM4ETOP2ATOP2BALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1044118-C | 7-isoindolinyl-quinolone derivatives and process for their preparation | BAYER AG (DE) | 1999-07-14 | — | — | CN | disclosed |
| CN-1189494-A | Substituted isoazalene compound | BAYER AG (DE) | 1998-08-05 | — | — | CN | disclosed |