Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.58 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084266 | 0.87 | TOP2A (0.64) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL10330771 | 0.86 | TOP2A (0.60) | TOP2ATOP2BPOLBMEN1KMT2A | |
| SCHEMBL4482132 | 0.85 | ALDH1A1 (0.58) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL10627007 | 0.85 | KCNH2 (0.48) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL6217925 | 0.85 | TOP2A (0.61) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL10915183 | 0.84 | TOP2A (0.43) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL27340789 | 0.82 | KDM4E (0.55) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL10631361 | 0.81 | TOP2A (0.61) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL6217009 | 0.81 | ALDH1A1 (0.60) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL9149649 | 0.81 | TOP2A (0.67) | TOP2ATOP2BPOLBALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205029-A2 | Quinolinecarboxylic acids with an antibacterial activity | BAYER AG (DE) | 1986-12-17 | — | — | EP | disclosed |