Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21565910 | 0.93 | KDM4E (0.36) | OPRL1TLR9TLR8TLR7KDM4E | |
| SCHEMBL27131127 | 0.81 | TLR9 (0.33) | TLR9TLR8TLR7 | |
| SCHEMBL27270856 | 0.81 | TLR9 (0.36) | OPRL1TLR9TLR8TLR7 | |
| SCHEMBL24850142 | 0.75 | HTR2A (0.34) | TLR9TLR8TLR7 | |
| SCHEMBL25928025 | 0.74 | TLR9 (0.31) | TLR9TLR8TLR7 | |
| SCHEMBL29210935 | 0.73 | NOS3 (0.41) | OPRL1KDM4EHTTCCR1CCR5 | |
| SCHEMBL25696540 | 0.72 | OPRL1 (0.36) | OPRL1TLR9TLR7KDM4EHTT | |
| SCHEMBL23620095 | 0.72 | LRRK2 (0.49) | — | |
| SCHEMBL23971149 | 0.71 | LRRK2 (0.32) | OPRL1TLR9TLR8TLR7 | |
| SCHEMBL31214511 | 0.71 | NOS2 (0.36) | OPRL1KDM4EHTTKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |