Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7557991 | 0.91 | ACHE (0.55) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6989606 | 0.91 | ACHE (0.55) | ACHEBCHE | |
| Maleic Acid SCHEMBL27339115 | 0.82 | ACHE (0.69) | HRH3ACHEBCHECCR3 | |
| Maleic Acid SCHEMBL27339116 | 0.82 | ACHE (0.69) | HRH3ACHEBCHECCR3 | |
| SCHEMBL6989630 | 0.82 | ACHE (0.64) | HRH3ACHEBCHE | |
| Maleic Acid SCHEMBL27352164 | 0.80 | ACHE (0.69) | ACHEBCHE | |
| Maleic Acid SCHEMBL27342890 | 0.80 | ACHE (0.69) | HRH3ACHEBCHECCR3 | |
| Maleic Acid SCHEMBL27342891 | 0.80 | ACHE (0.69) | HRH3ACHEBCHECCR3 | |
| Maleic Acid SCHEMBL27352167 | 0.80 | ACHE (0.69) | ACHEBCHE | |
| SCHEMBL8299035 | 0.80 | ACHE (0.58) | HRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1044242-C | Heterocyclic-cyclic amine derivatives | PFIZER (US) | 1999-07-21 | — | — | CN | disclosed |