Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388135 | 0.88 | PPARA (0.45) | POLBPPARAHDAC6LOXL2APP | |
| SCHEMBL24963247 | 0.81 | LOXL2 (0.59) | POLBPPARALOXL2APPDYRK1A | |
| SCHEMBL507904 | 0.78 | PPARA (0.45) | POLBPPARAHDAC6LOXL2APP | |
| SCHEMBL27281641 | 0.78 | DYRK1A (0.44) | PPARAHDAC6LOXL2DYRK1ATRPV1 | |
| SCHEMBL507628 | 0.77 | PPARA (0.49) | PPARAAPPDYRK1AGAAALDH1A1 | |
| SCHEMBL27948402 | 0.76 | LOXL2 (0.66) | PPARAHDAC6LOXL2TRPV1NPC1 | |
| SCHEMBL27399288 | 0.76 | NPC1 (0.43) | HDAC6LOXL2DYRK1ANPC1MAPK1 | |
| SCHEMBL12298168 | 0.72 | PPARA (0.48) | PPARAAPPDYRK1AGAAALDH1A1 | |
| SCHEMBL1748230 | 0.72 | PPARA (0.48) | PPARALOXL2APPDYRK1ANPC1 | |
| SCHEMBL9808445 | 0.72 | CYP3A4 (0.51) | PPARAAPPNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1097052-C | Process for prodn. of amidinoindole derivatives and salts thereof | DAIICHI SEIYAKU CO (JP) | 2002-12-25 | — | — | CN | disclosed |
| CN-1062865-C | Process for production of amidinobenzofuran and amidionbenzothiophen derivatives and salt thereof | DAIICHI SEIYAKU CO (JP) | 2001-03-07 | — | — | CN | disclosed |
| CN-1049434-C | Aromatic amidine derivatives and pharmaceutically acceptable salts thereof | DAIICHI SEIYAKU CO (JP) | 2000-02-16 | — | — | CN | disclosed |
| CN-1168885-A | Process for prodn. of amidinoindole derivatives and salts thereof | DAIICHI SEIYAKU CO (JP) | 1997-12-31 | — | — | CN | disclosed |
| CN-1168886-A | Process for production of amidinobenzofuran and amidionbenzothiophen derivatives and salt thereof | DAIICHI SEIYAKU CO (JP) | 1997-12-31 | — | — | CN | disclosed |
| CN-1072677-A | Aromatic amidine derivative and salt thereof | DAIICHI SEIYAKU CO (JP) | 1993-06-02 | — | — | CN | disclosed |