Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951534 | 0.94 | HSD11B1 (0.60) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL951786 | 0.90 | HSD11B1 (0.63) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL954965 | 0.87 | KMT2A (0.60) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL22469041 | 0.86 | HSD11B1 (0.62) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL3333381 | 0.85 | ALDH1A1 (0.51) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL30275177 | 0.84 | MAPK1 (0.54) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL29080121 | 0.84 | SMN1; SMN2 (0.55) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL2063483 | 0.83 | USP30 (0.58) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL2063481 | 0.83 | USP30 (0.58) | HSD11B1CTSLCTSBCTSKMAPK1 | |
| SCHEMBL6128873 | 0.83 | USP30 (0.58) | HSD11B1CTSLCTSBCTSKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |