SCHEMBL27347169

SCHEMBL27347169

CC(=O)Nc1ccc(C(=O)O)cn1.Cc1ccoc1

nearest known ligand 0.55

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 15/20 0.55
PTK2 Q05397 1/20 0.47
HCAR2 Q8TDS4 2/20 0.45
ADORA3 P0DMS8 1/20 0.44
ADORA2A P29274 1/20 0.44
ADORA2B P29275 1/20 0.44
KMT2A Q03164 1/20 0.43
CYP1A2 P05177 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL82675 0.85 HCAR3 (0.68) HCAR3PTK2HCAR2KMT2ACYP1A2
Toluene SCHEMBL9060786 0.83 HCAR3 (0.63) HCAR3PTK2HCAR2
SCHEMBL27335268 0.80 HCAR3 (0.52) HCAR3PTK2HCAR2ADORA3ADORA2A
SCHEMBL27343709 0.80 KDM4E (0.62) HCAR3PTK2HCAR2KMT2A
SCHEMBL27349315 0.77 HCAR3 (0.50) HCAR3PTK2HCAR2ADORA3ADORA2A
Pyridine SCHEMBL5437479 0.77 HCAR3 (0.59) HCAR3PTK2HCAR2KMT2ACYP1A2
SCHEMBL5240204 0.75 HCAR3 (0.52) HCAR3HCAR2
SCHEMBL27347795 0.75 HCAR3 (0.52) HCAR3PTK2HCAR2ADORA3ADORA2A
SCHEMBL7093993 0.74 PTK2 (0.62) HCAR3PTK2ADORA3KMT2ACYP1A2
SCHEMBL28118455 0.74 PTK2 (0.54) HCAR3PTK2KMT2ACYP1A2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1061658-C Tricyclic benzazepine vasopressin antagonists AMERICAN CYANAMID CO (US) 2001-02-07 CN disclosed