Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613304 | 0.86 | MEN1 (0.51) | PRMT5MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL27343269 | 0.83 | HTR2C (0.64) | PRMT5MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL3772065 | 0.80 | HTR2A (0.49) | PRMT5MEN1KMT2AASH1LHDAC1 | |
| SCHEMBL27623160 | 0.79 | HDAC1 (0.46) | PRMT5MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL8186052 | 0.78 | MEN1 (0.58) | PRMT5MEN1KMT2AASH1LHDAC1 | |
| SCHEMBL8959689 | 0.78 | HTR2C (0.71) | PRMT5MEN1KMT2AASH1LKDM4E | |
| SCHEMBL8959700 | 0.78 | HTR2C (0.71) | PRMT5MEN1KMT2AASH1LKDM4E | |
| SCHEMBL8959518 | 0.78 | PER2 (0.40) | ASH1LHTR2AHTR2C | |
| SCHEMBL8959520 | 0.78 | PER2 (0.40) | ASH1LHTR2AHTR2C | |
| SCHEMBL665932 | 0.76 | MEN1 (0.56) | PRMT5MEN1KMT2AHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |