Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Malathion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malathion SCHEMBL3705116 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL124812 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL21693725 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL4749884 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL9253814 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL6737957 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL7092080 | 0.94 | ALDH1A1 (0.89) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL5134717 | 0.94 | ALDH1A1 (0.88) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL1691874 | 0.92 | ALDH1A1 (0.85) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL1692227 | 0.92 | ALDH1A1 (0.85) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 41093 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130877-A1 | TREATMENT OF NEURODEVELOPMENTAL DISORDERS | THE REGENTS OF THE UNIV OF CALIFORNIA (US) | 2026-05-14 | — | — | US | claimed |
| EP-4734763-A1 | COMPOSITIONS, METHODS AND DEVICES FOR CONTROL AND MONITORING INSECTS | Agriculture Victoria Services Pty Ltd (AU) | 2026-05-06 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4734762-A1 | BAIT COMPOSITIONS | FMC Corporation (US) | 2026-05-06 | — | — | EP | claimed |
| US-20260114446-A1 | Compositions, Methods and Devices for Control and Monitoring Insects | AGRICULTURE VICTORIA SERVICES PTY LTD (AU) | 2026-04-30 | — | — | US | claimed |
| EP-4723893-A2 | COMPOSITIONS AND METHODS TO MITIGATE PHYTOTOXIC EFFECTS OF AGRICHEMICALS | Ascribe Bioscience Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4719059-A1 | INCREASED PALATABILITY OF INSECTICIDAL INSECT BAITS | Bio Logic Crop Science, S.L. (ES) | 2026-04-08 | — | — | EP | claimed |
| US-20260083129-A1 | PYRAZOLE AMIDE INSECTICIDES | FMC CORP (US) | 2026-03-26 | — | — | US | claimed |
| US-20260083130-A1 | NOVEL SULFONATE BENZAMIDE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | FMC CORP (US) | 2026-03-26 | — | — | US | claimed |
| EP-4710766-A1 | MIXTURES OF AMBRUTICIN WITH AT LEAST ONE FURTHER PESTICIDE | BASF SE (DE) | 2026-03-18 | — | — | EP | claimed |
| US-4173094-A | Method for treating ground surfaces with a toxic agent | NICHOLS WALLACE H JR | 1979-11-06 | — | — | US | claimed |
| US-4123525-A | Sublimable insecticidal compositions containing triisopropyl- or tritertiary-butyl-s-trioxane carriers | OGAWA & CO., LTD. (JP) | 1978-10-31 | — | — | US | claimed |
| US-4107292-A | POLYAMIDES, POLYUREAS, INSECTICIDES | AKZONA INCORPORATED (US) | 1978-08-15 | — | — | US | claimed |
| US-4103450-A | LOW DENSITY WEB IMPREGNATED WITH INSECTICIDE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1978-08-01 | — | — | US | claimed |
| US-4083691-A | Method for detecting contaminants in water | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1978-04-11 | — | — | US | claimed |
| US-4064237-A | Synergistic pesticidal mixtures of phosalone and malathion and process for controlling arthropods therewith | RHODIA, INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4034080-A | 4-METHYL-3-HEPTANOL, 2,4-DIMETHYL-5-ETHYL-6,8-DIOXA-BICYCLO(3.2.1)OCTANE, ALPHA-CUBEBENE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1977-07-05 | — | — | US | claimed |
| US-4003981-A | PESTICIDE CARRIER WITH MALATHION ABSORPTION; MATTING AGENTS | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) | 1977-01-18 | — | — | US | claimed |
| US-3992532-A | ALKALI LIGNINS, SOLVENTS, WATER INSOLUBLE TOXICANTS | WESTVACO CORPORATION (US) | 1976-11-16 | — | — | US | claimed |
| US-3961043-A | CONTAINING LINOLEIC OR LINOLENIC ACID | MOBIL OIL CORPORATION (US) | 1976-06-01 | — | — | US | claimed |