Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Malathion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.94 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malathion SCHEMBL3705116 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL124812 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL27358 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL21693725 | 0.95 | ALDH1A1 (0.97) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL4749884 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL6737957 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL7092080 | 0.91 | ALDH1A1 (0.89) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL5134717 | 0.91 | ALDH1A1 (0.88) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL1691874 | 0.89 | ALDH1A1 (0.85) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL1692227 | 0.89 | ALDH1A1 (0.85) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5474998-A | Pesticides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-12-12 | — | — | US | disclosed |
| WO-1994025440-A1 | ARTHROPODICIDAL AND NEMATOCIDAL HETEROCYCLIC SULPHONATES | DUNLENA PTY. LIMITED (AU) | 1994-11-10 | — | — | WO | disclosed |
| EP-0577712-A1 | FUNGICIDAL 4-THIOXOOXAZOLIDIN-2-ONES AND 4-IMINOOXAZOLINDIN-2-ONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-01-12 | — | — | EP | disclosed |
| EP-0565574-A1 | ARTHROPODICIDAL CARBOXANILIDES. | DU PONT (US) | 1993-10-20 | — | — | EP | disclosed |
| EP-0561961-A1 | NOVEL HETEROCYCLIC AMIDINES AND GUANIDINES AS PLANT FUNGICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0555388-A1 | INSECTICIDAL, ACARICIDAL AND FUNGICIDAL AMINOPYRIMIDINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0533734-A1 | FUNGICIDAL IMINOOXAZOLIDINONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1993005024-A1 | ARTHROPODICIDAL ANILIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0530264-A1 | ARTHROPODICIDAL TETRAHYDROPYRIDAZINES. | DU PONT (US) | 1993-03-10 | — | — | EP | disclosed |
| EP-0515525-A1 | ARTHROPODICIDAL TRICHLOROMETHYLBENZYLAMINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-12-02 | — | — | EP | disclosed |
| WO-1987006430-A1 | FUNGICIDAL TRIAZOLES AND IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-11-05 | — | — | WO | disclosed |
| EP-0097464-B1 | INSECTICIDAL COMPOSITIONS HAVING HIGH CONCENTRATION OF ACTIVE INGREDIENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-04-22 | — | — | EP | disclosed |
| EP-0146610-A4 | SUBSTITUTED BENZOPENTATHIEPINS, PROCESS THEREFOR AND INTERMEDIATES. | DU PONT (US) | 1986-02-20 | — | — | EP | disclosed |
| EP-0148026-A2 | Fungicidal imidazoles and triazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-07-10 | — | — | EP | disclosed |
| EP-0146610-A1 | SUBSTITUTED BENZOPENTATHIEPINS, PROCESS THEREFOR AND INTERMEDIATES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-07-03 | — | — | EP | disclosed |
| WO-1985001732-A1 | 8-SUBSTITUTED PYRAZOLOPENTATHIEPINS AND RELATED COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-25 | — | — | WO | disclosed |
| EP-0137717-A2 | Fungicidal triazole and imidazole compounds | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-17 | — | — | EP | disclosed |
| EP-0137718-A2 | Fungicidal triazoleethanols | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-17 | — | — | EP | disclosed |
| WO-1984004921-A1 | SUBSTITUTED BENZOPENTATHIEPINS, PROCESS THEREFOR AND INTERMEDIATES | DU PONT (US) | 1984-12-20 | — | — | WO | disclosed |
| EP-0047648-A2 | Slow release pesticide formulation | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-03-17 | — | — | EP | disclosed |