Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Malathion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malathion SCHEMBL124812 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL27358 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL21693725 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL4749884 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL9253814 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL6737957 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| Malathion SCHEMBL7092080 | 0.94 | ALDH1A1 (0.89) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL5134717 | 0.94 | ALDH1A1 (0.88) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL1691874 | 0.92 | ALDH1A1 (0.85) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 | |
| SCHEMBL1692227 | 0.92 | ALDH1A1 (0.85) | ALDH1A1CYP3A4ALOX15HSD17B10CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431361-B1 | Use of stabilizers for agrochemical compositions | BAYER AGROCHEM KK (JP) | 1994-02-23 | — | — | EP | claimed |
| EP-0431362-B1 | Stabilized agrochemical compositions | BAYER AGROCHEM KK (JP) | 1993-11-03 | — | — | EP | claimed |
| EP-0431361-A1 | Use of stabilizers for agrochemical compositions | NIHON BAYER AGROCHEM K.K. (JP) | 1991-06-12 | — | — | EP | claimed |
| EP-0431362-A1 | Stabilized agrochemical compositions | NIHON BAYER AGROCHEM K.K. (JP) | 1991-06-12 | — | — | EP | claimed |
| JP-56152406-A | — | — | None | — | — | JP | disclosed |
| EP-2391207-B1 | PESTICIDAL CONTROL DEVICE WITH HIGH LOAD OF ACTIVE INGREDIENT | BAYER IP GMBH (DE) | 2018-03-28 | — | — | EP | disclosed |
| US-9801355-B2 | Pesticidal control device with high load of active ingredient | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-10-31 | — | — | US | disclosed |
| US-9493805-B2 | Enzymatic biosensors with enhanced activity retention for detection of organic compounds | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-9420780-B2 | Composition, method for producing the composition, and phytosanitary formulation containing same | RHODIA OPERATIONS (FR) | 2016-08-23 | — | — | US | disclosed |
| US-9237747-B2 | Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and insecticides | DOW AGROSCIENCES LLC (US) | 2016-01-19 | — | — | US | disclosed |
| US-20160000066-A1 | Furfural derivatives as a vehicle | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) | 2016-01-07 | — | — | US | disclosed |
| US-20150373947-A1 | PESTICIDAL CONTROL DEVICE WITH HIGH LOAD OF ACTIVE INGREDIENT | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-31 | — | — | US | disclosed |
| EP-0243694-A2 | Pesticide compositions and method | STAUFFER CHEMICAL COMPANY (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0158449-A1 | Microcapsules and microencapsulation process | STAUFFER CHEMICAL COMPANY (US) | 1985-10-16 | — | — | EP | disclosed |
| US-4456569-A | FORMING PROTECTIVE COLLOID USING GRAFT COPOLYMER OF POLYVINYL ALCOHOL AND METHYL VINYL ETHER-MALEIC ACID | STAUFFER CHEMICAL COMPANY (US) | 1984-06-26 | — | — | US | disclosed |
| US-4448929-A | PROTECTIVE COLLOID FOR INTERFACIAL POLYMERIZATION | STAUFFER CHEMICAL COMPANY (US) | 1984-05-15 | — | — | US | disclosed |
| JP-S56152406-A | INSECTICIDE | HOKKO CHEM IND CO LTD | 1981-11-26 | — | — | JP | disclosed |
| US-4263321-A | N-HYDROXYPROPYLLAURAMIDE TO KILL ECTOPARISITES | BLOCK DRUG COMPANY INC. (US) | 1981-04-21 | — | — | US | disclosed |
| US-4238499-A | TOXIC TO OVA AND OTHER INSECT SPECIES | BLOCK DRUG COMPANY INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4146619-A | DIMETHICONE, PHENYLDIMETHICONE, SIMETHICONE | BLOCK DRUG COMPANY INC. (US) | 1979-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000066-A1 | Furfural derivatives as a vehicle | C1R, FRG1, FAR1 | ALDH1A1 563/4885CYP3A4 1089/4885ALOX15 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.