Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 10/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029480 | 1.00 | CYP1A2 (0.52) | CYP1A2CD274PDCD1SPHK1KDM4E | |
| SCHEMBL1818678 | 1.00 | CYP1A2 (0.52) | CYP1A2CD274PDCD1SPHK1KDM4E | |
| SCHEMBL31457101 | 0.88 | SPHK1 (0.60) | CD274PDCD1SPHK1KDM4ESMN1; SMN2 | |
| SCHEMBL27630427 | 0.86 | SMN1; SMN2 (0.46) | SPHK1KDM4ESMN1; SMN2TDP1MBTD1 | |
| SCHEMBL27358578 | 0.85 | ALDH1A1 (0.52) | SPHK1KDM4ESMN1; SMN2TDP1MEN1 | |
| SCHEMBL1972076 | 0.84 | CYP1A2 (0.60) | CYP1A2CD274PDCD1SPHK1SMN1; SMN2 | |
| SCHEMBL1819248 | 0.84 | CYP1A2 (0.60) | CYP1A2CD274PDCD1SPHK1SMN1; SMN2 | |
| SCHEMBL2587055 | 0.84 | CYP1A2 (0.60) | CYP1A2CD274PDCD1SPHK1SMN1; SMN2 | |
| SCHEMBL1815987 | 0.84 | NPBWR1 (0.53) | CYP1A2CD274PDCD1SPHK1KDM4E | |
| SCHEMBL3148367 | 0.84 | NPBWR1 (0.53) | CYP1A2CD274PDCD1SPHK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4565562-A1 | PYRROLIDINE-2-CARBOXAMIDE DERIVATIVES AS PROSTAGLANDIN E2 RECEPTOR 4 (EP4) AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL AND PULMONARY DISEASES | Nxera Pharma UK Limited (GB) | 2025-06-11 | — | — | EP | disclosed |
| CN-119790036-A | Pyrrolidine-2-carboxamide derivatives as prostaglandin E2 receptor 4 (EP 4) agonists for the treatment of gastrointestinal and pulmonary diseases | 奈克斯拉制药英国有限公司 | 2025-04-08 | — | — | CN | disclosed |
| WO-2024028603-A1 | PYRROLIDINE-2-CARBOXAMIDE DERIVATIVES AS PROSTAGLANDIN E2 RECEPTOR 4 (EP4) AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL AND PULMONARY DISEASES | HEPTARES THERAPEUTICS LIMITED (GB) | 2024-02-08 | — | — | WO | disclosed |
| WO-2024028603-A1 | PYRROLIDINE-2-CARBOXAMIDE DERIVATIVES AS PROSTAGLANDIN E2 RECEPTOR 4 (EP4) AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL AND PULMONARY DISEASES | HEPTARES THERAPEUTICS LIMITED (GB) | 2024-02-08 | — | — | WO | disclosed |