Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27367383 | 0.97 | CACNA2D1 (0.39) | KCNH2RETAURKAMETKIT | |
| SCHEMBL27363567 | 0.85 | DRD2 (0.47) | KCNH2RETAURKAMETKIT | |
| SCHEMBL27363630 | 0.84 | CHRM4 (0.43) | RETCHRM4MAPTHTR1AHTR7 | |
| SCHEMBL27363705 | 0.83 | DRD2 (0.47) | KCNH2RETCHRM4MAPTHTR1A | |
| SCHEMBL27362988 | 0.82 | KCNH2 (0.41) | KCNH2KITCHRM4HTR1ACACNA2D1 | |
| SCHEMBL4517601 | 0.81 | HTR3A (0.51) | HTR3AKDM4E | |
| SCHEMBL27362867 | 0.80 | DRD2 (0.50) | RETAURKAMETKITSRC | |
| SCHEMBL27365078 | 0.79 | ALDH1A1 (0.41) | KCNH2MAPTCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24735175 | 0.77 | PDE10A (0.48) | KDM4E | |
| SCHEMBL30612346 | 0.77 | PDE10A (0.48) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |