Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665721 | 0.82 | KCNH2 (0.61) | KCNH2DRD2DRD3ADRB1FFAR4 | |
| SCHEMBL27364244 | 0.81 | NOTUM (0.49) | KCNH2NOTUMDRD2DRD3ADRB1 | |
| SCHEMBL27365087 | 0.80 | KCNH2 (0.62) | KCNH2ADRB1FFAR4HTR7MAPT | |
| SCHEMBL27367012 | 0.79 | ADRB1 (0.58) | KCNH2NOTUMADRB1FFAR4HTR7 | |
| SCHEMBL27364237 | 0.79 | NOTUM (0.49) | KCNH2NOTUMADRB1FFAR4HTR7 | |
| SCHEMBL519930 | 0.78 | KDM4E (0.51) | KCNH2PRKDCHTR7TP53MAPT | |
| SCHEMBL519583 | 0.75 | PRKDC (0.41) | PRKDCHTR7MAPT | |
| SCHEMBL519584 | 0.75 | PRKDC (0.41) | PRKDCHTR7MAPT | |
| SCHEMBL519585 | 0.75 | PRKDC (0.41) | PRKDCHTR7MAPT | |
| SCHEMBL520304 | 0.74 | LMNA (0.60) | HTR7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |