Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | BPTF | Q12830 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364237 | 0.85 | NOTUM (0.49) | ADRB1NOTUMBPTFKCNH2HTR7 | |
| SCHEMBL27364244 | 0.85 | NOTUM (0.49) | ADRB1NOTUMBPTFKCNH2HTR7 | |
| SCHEMBL27366226 | 0.82 | ADRB1 (0.61) | ADRB1KCNH2HTR7HTR1AFFAR4 | |
| SCHEMBL27363469 | 0.79 | KCNH2 (0.49) | ADRB1NOTUMKCNH2HTR7FFAR4 | |
| SCHEMBL19706125 | 0.78 | NOTUM (0.56) | ADRB1NOTUMBPTFKCNH2HTR7 | |
| SCHEMBL30502285 | 0.77 | ADRB1 (0.68) | ADRB1KCNH2HTR7HTR1AADRA1D | |
| SCHEMBL3588462 | 0.76 | SIGMAR1 (0.49) | ADRB1KCNH2CNR1HTR1AADRA1B | |
| SCHEMBL3588458 | 0.76 | SIGMAR1 (0.49) | ADRB1KCNH2CNR1HTR1AADRA1B | |
| SCHEMBL81365 | 0.75 | ADRB1 (1.00) | ADRB1KCNH2HTR7HTR1AKHK | |
| SCHEMBL29391951 | 0.75 | ADRB1 (1.00) | ADRB1KCNH2HTR7HTR1AKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |