Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073594 | 0.83 | TSHR (0.45) | ALOX5KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6797977 | 0.82 | ALOX5 (0.44) | ALOX5KDM4EALDH1A1SMN1; SMN2LDHA | |
| SCHEMBL5005300 | 0.81 | CA12 (0.53) | ALOX5KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL7873244 | 0.81 | KMT2A (0.46) | ALOX5KDM4ETSHRALDH1A1CCR2 | |
| SCHEMBL29812990 | 0.81 | CCR2 (0.54) | KDM4EHSD17B10ALDH1A1CCR2SMN1; SMN2 | |
| SCHEMBL7884274 | 0.81 | CCR2 (0.43) | ALOX5KDM4EALDH1A1CCR2SMN1; SMN2 | |
| SCHEMBL22042092 | 0.80 | KDM4E (0.50) | ALOX5KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL7873379 | 0.80 | ALDH1A1 (0.48) | KDM4EHSD17B10TSHRALDH1A1RXFP1 | |
| SCHEMBL27378256 | 0.80 | ALOX5 (0.49) | ALOX5KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL6798023 | 0.80 | ALDH1A1 (0.39) | ALOX5KDM4EALDH1A1PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067988-C | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICS K K (JP) | 2001-07-04 | — | — | CN | disclosed |
| CN-1136038-A | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICS K K (JP) | 1996-11-20 | — | — | CN | disclosed |
| CN-1106800-A | Indoloylguanidine derivatives | SUMITOMO PHARMA (JP) | 1995-08-16 | — | — | CN | disclosed |