Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81909 | 0.91 | HRH4 (0.51) | HTR3AHRH4LMNAPOLBHDAC3 | |
| SCHEMBL17972976 | 0.86 | DHFR (0.49) | LMNADHFRSIGMAR1 | |
| SCHEMBL27368275 | 0.85 | TAAR1 (0.44) | DHFRALDH1A1CYP1A2HSD17B10SIGMAR1 | |
| SCHEMBL17973027 | 0.84 | ALOX15 (0.45) | DHFRALDH1A1SIGMAR1HTR1A | |
| SCHEMBL19145298 | 0.84 | MEN1 (0.53) | DHFRALDH1A1CYP1A2HSD17B10SIGMAR1 | |
| SCHEMBL81489 | 0.84 | HRH4 (0.46) | HTR3AHRH4LMNAPOLBHDAC3 | |
| SCHEMBL8525435 | 0.81 | DHFR (0.48) | LMNADHFRALDH1A1 | |
| SCHEMBL20463090 | 0.81 | HDAC6 (0.53) | DHFRALDH1A1CYP1A2HSD17B10SIGMAR1 | |
| SCHEMBL27363464 | 0.81 | CASP1 (0.42) | LMNAPOLBDHFRALDH1A1CYP1A2 | |
| SCHEMBL27363461 | 0.81 | KCNH2 (0.42) | HTR3AHRH4LMNAPOLBHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |