Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metolcarb. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metolcarb SCHEMBL27347183 | 0.91 | LMNA (0.57) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL118244 | 0.91 | LMNA (0.65) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL29413999 | 0.91 | LMNA (0.65) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL8024716 | 0.89 | LMNA (0.62) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL11000289 | 0.89 | LMNA (0.62) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL7079404 | 0.89 | LMNA (0.62) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL11681132 | 0.89 | LMNA (0.62) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL28786421 | 0.89 | LMNA (0.62) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL1879809 | 0.87 | LMNA (0.61) | LMNAALDH1A1MAPK1FAAHCYP3A4 | |
| Metolcarb SCHEMBL258226 | 0.86 | LMNA (0.59) | LMNAALDH1A1MAPK1FAAHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053085-C | Composition for killing snail | ZHAO XIAOWU (CN) | 2000-06-07 | — | — | CN | claimed |
| CN-1698437-A | Pesticide for preventing mollusks such as snail and slug | ZHAO XIAOWU (CN) | 2005-11-23 | — | — | CN | disclosed |
| CN-1053085-C | Composition for killing snail | ZHAO XIAOWU (CN) | 2000-06-07 | — | — | CN | disclosed |