Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27366659 | 0.85 | MAPK1 (0.42) | MAPK1DRD2DRD4MAPTHRH3 | |
| SCHEMBL27363818 | 0.76 | MAPK1 (0.47) | MAPK1DRD2DRD4MAPTGFER | |
| SCHEMBL10161179 | 0.74 | MAPK1 (0.47) | MAPK1DRD2DRD4 | |
| SCHEMBL27363819 | 0.74 | ACHE (0.41) | ACHEHRH3 | |
| SCHEMBL10132281 | 0.73 | MAPK1 (0.51) | MAPK1DRD2DRD4MAPTGFER | |
| SCHEMBL27367505 | 0.73 | MAPK1 (0.43) | MAPK1DRD2DRD4MAPTHRH3 | |
| SCHEMBL15859012 | 0.72 | MAPK1 (0.50) | MAPK1DRD2DRD4MAPTHRH3 | |
| SCHEMBL18948460 | 0.72 | MAPK1 (0.50) | MAPK1DRD2DRD4MAPTHRH3 | |
| SCHEMBL16549649 | 0.71 | MAPK1 (0.69) | MAPK1DRD2DRD4MAPTOPRM1 | |
| SCHEMBL26521114 | 0.71 | ACHE (0.38) | ACHEHRH3SMN1; SMN2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |