Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27367505 | 0.85 | MAPK1 (0.43) | MAPK1SMN1; SMN2DRD2DRD4LMNA | |
| SCHEMBL27363822 | 0.85 | MAPK1 (0.40) | MAPK1DRD2DRD4MAPTCACNA2D1 | |
| SCHEMBL2610122 | 0.79 | SMN1; SMN2 (0.47) | MAPK1SMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL19003699 | 0.79 | SMN1; SMN2 (0.47) | MAPK1SMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL27372185 | 0.79 | SMN1; SMN2 (0.47) | MAPK1SMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL27362860 | 0.79 | MAPT (0.50) | SMN1; SMN2DRD2POLBMAPTGFER | |
| SCHEMBL27364621 | 0.79 | MAPT (0.47) | SMN1; SMN2DRD2POLBMAPTCACNA2D1 | |
| SCHEMBL10132281 | 0.78 | MAPK1 (0.51) | MAPK1SMN1; SMN2DRD2DRD4LMNA | |
| SCHEMBL27365978 | 0.76 | MAPK1 (0.42) | MAPK1SMN1; SMN2DRD2DRD4MAPT | |
| SCHEMBL24834707 | 0.76 | MAPT (0.47) | DRD2MAPTGFERCACNA2D1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |