SCHEMBL27366451

SCHEMBL27366451

O=C(Nc1ccc(Oc2ncnc3[nH]c(-c4ccccc4)cc23)cc1)c1cccn(-c2ccc(F)cc2)c1=O

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 15/20 0.63
AXL P30530 15/20 0.61
MET P08581 5/20 0.59
MST1R Q04912 1/20 0.55
TYRO3 Q06418 2/20 0.54
ABL1 P00519 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366454 0.91 MERTK (0.65) MERTKAXLMETMST1RTYRO3
SCHEMBL27366453 0.89 AXL (0.66) MERTKAXLMETTYRO3
SCHEMBL27366035 0.84 MERTK (0.68) MERTKAXLMETTYRO3
SCHEMBL27365552 0.83 MERTK (0.65) MERTKAXLMETMST1RTYRO3
SCHEMBL1895590 0.82 CSF1R (0.64) MERTK
SCHEMBL24196303 0.81 MERTK (0.64) MERTKAXLMETTYRO3ABL1
SCHEMBL30381010 0.81 MERTK (0.64) MERTKAXLMETTYRO3ABL1
SCHEMBL24196306 0.80 MET (0.62) MERTKAXLMETTYRO3ABL1
SCHEMBL30381151 0.80 MET (0.62) MERTKAXLMETTYRO3ABL1
SCHEMBL2478035 0.79 MET (0.68) MERTKAXLMETTYRO3ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed