Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.44 |
| ▸ | HTR3B | O95264 | 3/20 | 0.44 |
| ▸ | HTR3A | P46098 | 3/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | ESRRB | O95718 | 2/20 | 0.38 |
| ▸ | ESRRG | P62508 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364129 | 0.83 | SCN1A (0.50) | ADRB1MAPTALDH1A1GPR119MEN1 | |
| Hydrochloric Acid SCHEMBL5208875 | 0.80 | KDM4E (0.47) | GPR119 | |
| SCHEMBL6132921 | 0.79 | ADRB1 (0.49) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL20579629 | 0.78 | OPRD1 (0.43) | MAPTALDH1A1GPR119MEN1KMT2A | |
| SCHEMBL171731 | 0.78 | ADRB1 (0.50) | ADRB1MAPTALDH1A1GPR119MEN1 | |
| Hydrochloric Acid SCHEMBL31753304 | 0.77 | HRH3 (0.51) | MAPTALDH1A1GPR119 | |
| SCHEMBL6645952 | 0.77 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL81940 | 0.77 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL23422562 | 0.75 | ADRB1 (0.62) | ADRB1MEN1KMT2A | |
| SCHEMBL18311444 | 0.75 | ADRB1 (0.68) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |