Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12082219 | 0.77 | MAPT (0.51) | EBPADRB1 | |
| SCHEMBL22542091 | 0.74 | MAPT (0.51) | ADRB1 | |
| SCHEMBL12073571 | 0.73 | CHRM5 (0.48) | ADRB1 | |
| SCHEMBL24834707 | 0.72 | MAPT (0.47) | EBPADRB1 | |
| SCHEMBL15499062 | 0.72 | MAPT (0.47) | ADRB1 | |
| SCHEMBL19832328 | 0.71 | ADRB1 (0.52) | ADRB1CYP3A4MAPK1HSD17B10 | |
| SCHEMBL18872636 | 0.71 | MAPT (0.46) | ADRB1 | |
| SCHEMBL22537876 | 0.70 | ADRB1 (0.50) | ADRB1CYP3A4MAPK1HSD17B10 | |
| SCHEMBL24803641 | 0.69 | MAPT (0.43) | EBPOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL30984879 | 0.68 | SIRT6 (0.57) | ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |