Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428059 | 0.95 | GAA (0.53) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8425819 | 0.84 | MEN1 (0.60) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8425391 | 0.84 | GAA (0.43) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL4664663 | 0.83 | GAA (0.76) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6953402 | 0.82 | GAA (0.60) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6946002 | 0.79 | MAPT (0.55) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5462191 | 0.78 | MAPT (0.54) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8427551 | 0.78 | GAA (0.58) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5454653 | 0.76 | MAPT (0.54) | GAAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8015635 | 0.75 | MAPT (0.54) | GAAMEN1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066138-C | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 2001-05-23 | — | — | CN | disclosed |
| CN-1141291-A | 4-(Arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 1997-01-29 | — | — | CN | disclosed |