Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | GAA | P10253 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664663 | 0.88 | GAA (0.76) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL6953402 | 0.88 | GAA (0.60) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL8427551 | 0.83 | GAA (0.58) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL8428059 | 0.80 | GAA (0.53) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL5462729 | 0.77 | GAA (0.63) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL5459337 | 0.76 | MAPT (0.62) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL5928911 | 0.75 | GAA (0.60) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL10497099 | 0.75 | LMNA (0.44) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL9382338 | 0.75 | TBXAS1 (0.53) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL9382351 | 0.75 | MEN1 (0.44) | MEN1KMT2AGAAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066138-C | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 2001-05-23 | — | — | CN | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |
| CN-1141291-A | 4-(Arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 1997-01-29 | — | — | CN | disclosed |