Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427551 | 0.94 | GAA (0.58) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4664663 | 0.89 | GAA (0.76) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8425819 | 0.88 | MEN1 (0.60) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8633892 | 0.83 | SHMT2 (0.70) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL13597563 | 0.83 | GAA (0.56) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8428093 | 0.82 | GAA (0.47) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL6947831 | 0.81 | SHMT2 (0.58) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8425552 | 0.80 | POLB (0.55) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8760381 | 0.80 | GAA (0.79) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL4620529 | 0.80 | GAA (0.55) | GAAALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |