Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364242 | 0.87 | BAZ2A (0.33) | — | |
| SCHEMBL27366232 | 0.84 | CACNA2D1 (0.41) | CACNA2D1CACNA1BCACNB1SIGMAR1 | |
| SCHEMBL82186 | 0.79 | KDM4E (0.39) | DRD2DRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL82200 | 0.75 | CHRNA7 (0.47) | DRD2DRD3KCNH2 | |
| SCHEMBL27362860 | 0.75 | MAPT (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CDRD2 | |
| SCHEMBL24319476 | 0.74 | NCF1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL25571706 | 0.74 | NCF1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL23173902 | 0.74 | NCF1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL82260 | 0.73 | CHKA (0.42) | DRD2DRD3KCNH2 | |
| SCHEMBL3436997 | 0.72 | NCF1 (0.52) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |