Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP4 | P49662 | 1/20 | 0.32 |
| ▸ | CASP5 | P51878 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27367884 | 0.84 | CACNA2D1 (0.41) | CACNA2D1CACNA1BCACNB1SIGMAR1 | |
| SCHEMBL81908 | 0.77 | ADRB1 (0.47) | SIGMAR1 | |
| SCHEMBL27367743 | 0.75 | ADRB1 (0.57) | CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL82200 | 0.74 | CHRNA7 (0.47) | MEN1KMT2A | |
| SCHEMBL14422030 | 0.73 | GBA1 (0.48) | CACNA2D1CACNA1BCACNB1ACHEHTR4 | |
| SCHEMBL27368372 | 0.71 | ADRB1 (0.56) | CACNA2D1CACNA1BCACNB1MEN1KMT2A | |
| SCHEMBL27366226 | 0.71 | ADRB1 (0.61) | CACNA2D1CACNA1BCACNB1 | |
| Hydrochloric Acid SCHEMBL5573130 | 0.71 | GBA1 (0.47) | CACNA2D1CACNA1BCACNB1ACHE | |
| SCHEMBL27366889 | 0.70 | CASP1 (0.41) | CACNA2D1CACNA1BCACNB1CASP1CASP4 | |
| SCHEMBL26157301 | 0.70 | DRD2 (0.40) | CACNA2D1CACNA1BCACNB1CASP1CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |